{"id":6627,"date":"2022-09-05T12:22:25","date_gmt":"2022-09-05T12:22:25","guid":{"rendered":"https:\/\/www.diginerve.com\/?p=6627"},"modified":"2023-09-12T05:55:05","modified_gmt":"2023-09-12T05:55:05","slug":"pharmacokinetics-and-its-applicability-dr-sandeep-kaushal","status":"publish","type":"post","link":"https:\/\/www.diginerve.com\/blogs\/pharmacokinetics-and-its-applicability-dr-sandeep-kaushal\/","title":{"rendered":"Pharmacokinetics and its Applicability – Dr. Sandeep Kaushal"},"content":{"rendered":"

Pharmacology<\/strong><\/a> is the study of the interaction of drugs with biological systems. This includes research on the chemical makeup, biological processes, physiological and behavioral impacts, mechanisms of action, and both therapeutic and non-therapeutic applications of pharmaceuticals.<\/p>\n

Pharmacology is broadly categorized into two terms:<\/strong><\/p>\n

\"Pharma<\/p>\n

 <\/p>\n

PHARMACOKINETICS IN PHARMACOLOGY<\/strong><\/h2>\n

The term \u2018Pharmacokinetics\u2019 is derived from ancient Greek words, pharmakon<\/em> meaning \u2018drug\u2019 and kinetikos <\/em>meaning \u2018moving\u2019 or put in motion. Pharmacokinetics is a journey of a drug through the body, and in this, a drug passes through four different phases- Absorption, Distribution, Metabolism, and Excretion, which are called ADME properties.<\/em><\/p>\n

The selection and modification of drug-dose schedules are aided by pharmacokinetic parameters.<\/p>\n

Let\u2019s discuss the pharmacokinetic parameters:<\/p>\n

    \n
  1. ABSORPTION:<\/u><\/strong><\/li>\n<\/ol>\n

    Absorption is the movement of a drug to the site of action from the site of administration. Various factors affect the extent and rate of absorption of the drug, such as routes of drug administration, dosage form, physiochemical properties of the drug,\u00a0 bioavailability, pharmacogenetic factors, etc.<\/p>\n

    \"\"<\/p>\n

    First Pass Metabolism: It is a phenomenon in which a drug is metabolized or transformed at a specific site before the drug reaches its site of action or systemic circulation, resulting in a lower concentration of the active substance. Examples of the drugs that undergo this phenomenon in the liver are propranolol, lidocaine, and clomethiazole; in the gut wall are sex hormones.<\/p>\n

    In the case of intravenous or intra-arterial administration, the drug bypasses the first pass metabolism and enters the circulation directly.<\/p>\n

    Watch this free video of one of the best online pharmacology courses in MBBS<\/strong><\/p>\n